Search results for "Alzheimer's Disease Neuroimaging Initiative"

showing 4 items of 4 documents

Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative harm…

2017

Abstract Introduction A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Methods Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple …

Magnetic Resonance Imaging/methods/standardsMaleJaccard indexEpidemiologyComputer sciencemethods [Pattern Recognition Automated]Image ProcessingAutomated/methods/standardsHippocampusPattern Recognition Automatedddc:616.89methods [Magnetic Resonance Imaging]0302 clinical medicinemethods [Image Processing Computer-Assisted]Image Processing Computer-AssistedComputer-Assisted/methods/standardsHARPdiagnostic imaging [Hippocampus]Health Policy05 social sciencesOrgan SizeReference StandardsMagnetic Resonance ImagingHippocampal segmentationstandards [Image Processing Computer-Assisted]Psychiatry and Mental healthNeuroimaging/methods/standardsFemalemethods [Neuroimaging]Hippocampus/diagnostic imagingAlzheimer's Disease Neuroimaging InitiativeAlzheimer Disease/diagnostic imagingNeuroimagingPattern Recognition050105 experimental psychology03 medical and health sciencesCellular and Molecular NeuroscienceDevelopmental NeuroscienceNeuroimagingAlzheimer DiseaseHumans0501 psychology and cognitive sciencesddc:610Reference standardsAgedProtocol (science)standards [Magnetic Resonance Imaging]business.industryPattern recognitionGold standard (test)Neurology (clinical)Artificial intelligenceGeriatrics and Gerontologybusinessdiagnostic imaging [Alzheimer Disease]standards [Pattern Recognition Automated]Neurosciencestandards [Neuroimaging]030217 neurology & neurosurgeryAlzheimer's & Dementia
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Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology

2018

Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically affect discrete neuronal systems, but the underlying mechanisms that render some brain regions more vulnerable to Alzheimer's disease pathology than others remain largely unknown. Here we studied molecular properties underlying these distinct regional vulnerabilities by analysing Alzheimer's disease-typical neuroimaging patterns of amyloid deposition and neurodegeneration in relation to regional gene expression profiles of the human brain. Graded patterns of brain-wide vulnerability to amyloid deposition and neurodegeneration in Alzheimer's disease were estimated by contrasting multimodal amyloid-sensiti…

Male0301 basic medicinePathologyphysiology [Amyloidogenic Proteins]genetics [Transcriptome]genetics [Alzheimer Disease]Cohort StudiesTranscriptomepathology [Alzheimer Disease]metabolism [Amyloidogenic Proteins]methods [Magnetic Resonance Imaging]0302 clinical medicinepathology [Brain]Gene expressiongenetics [Genetic Predisposition to Disease]Aged 80 and overmethods [Positron-Emission Tomography]NeurodegenerationBrainNeurofibrillary TanglesHuman brainMagnetic Resonance Imagingmetabolism [Neurofibrillary Tangles]medicine.anatomical_structureFemalemethods [Neuroimaging]Alzheimer's Disease Neuroimaging InitiativeAmyloidmedicine.medical_specialtyAmyloidmetabolism [Amyloid beta-Peptides]Amyloidogenic ProteinsNeuroimagingtau ProteinsBiology03 medical and health sciencesAlzheimer DiseasemedicineHumansDementiaGenetic Predisposition to Diseaseddc:610metabolism [Amyloid]AgedAmyloid beta-PeptidesCyclin-dependent kinase 5medicine.diseasemetabolism [tau Proteins]030104 developmental biologyPositron-Emission Tomographypathology [Neurofibrillary Tangles]Neurology (clinical)Transcriptome030217 neurology & neurosurgeryBrain
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The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity

2014

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low…

MalePathologyDiagnostic criteriaEpidemiologyImage Processinggenetics [Alzheimer Disease]HippocampusFunctional LateralityImagingpathology [Alzheimer Disease]ddc:616.89methods [Magnetic Resonance Imaging]Computer-AssistedClinical trialsddc:150methods [Image Processing Computer-Assisted]ValidationImage Processing Computer-AssistedSegmentationHARPmedicine.diagnostic_testHealth PolicyOrgan SizeAlzheimer's diseaseMiddle Agedinstrumentation [Magnetic Resonance Imaging]Manual segmentationMagnetic Resonance ImagingPsychiatry and Mental healthMagnetic resonanceBiomedical ImagingManual segmentationFemalemethods [Neuroimaging]methods [Imaging Three-Dimensional]EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiativemedicine.medical_specialtyHippocampal volumetry; Magnetic resonance; Alzheimer's disease; Biomarkers; Diagnostic criteria; Enrichment; Clinical trials; Validation; Harmonized protocol; Standard operating procedures; Manual segmentationConcurrent validityClinical SciencesHarmonized protocolNeuroimagingArticleHippocampal volumetryCellular and Molecular NeuroscienceImaging Three-DimensionalDevelopmental NeuroscienceNeuroimagingClinical ResearchAlzheimer DiseasemedicineHumansddc:610AgedProtocol (science)ReproducibilityInternetbusiness.industryNeurosciencesReproducibility of ResultsMagnetic resonance imagingBrain DisordersStandard operating procedurespathology [Hippocampus]EnrichmentGeriatricsThree-DimensionalNeurology (clinical)Geriatrics and GerontologyAtrophyNuclear medicinebusinessBiomarkers
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2015

We present a method to discover discriminative brain metabolism patterns in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, facilitating the clinical diagnosis of Alzheimer's disease. In the work, the term "pattern" stands for a certain brain region that characterizes a target group of patients and can be used for a classification as well as interpretation purposes. Thus, it can be understood as a so-called "region of interest (ROI)". In the literature, an ROI is often found by a given brain atlas that defines a number of brain regions, which corresponds to an anatomical approach. The present work introduces a semi-data-driven approach that is based on learning the charac…

Multidisciplinarymedicine.diagnostic_testbusiness.industryComputer scienceModel selectionBrain atlasMagnetic resonance imagingPattern recognitionMixture modelmedicine.diseasecomputer.software_genreBrain regionNeuroimagingDiscriminative modelPositron emission tomographyVoxelRegion of interestmedicineArtificial intelligenceAlzheimer's diseaseNuclear medicinebusinesscomputerAlzheimer's Disease Neuroimaging InitiativePLOS ONE
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